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No influence of polymorphisms in catechol-O-methyltransferase was found being linked with postoperative oxycodone intake. The pharmacodynamics of oxycodone is generally depending on polymorphic enzymes CYP2D6 and CP3A.Intracellular adjustments transpiring adhering to the binding of the opioid agonist to a G-protein-coupled opioid receptor.Abnormal